The Effect of Tai Chi on Dynamic Balance in Younger Adults: Implication for Physical Therapy Practice

Purpose: The objective of this study was to investigate the effect of Tai Chi on the dynamic balance in younger, active community-based adults with no history of lower extremity injury or balance problems. Methods: Fourteen subjects (4 males / 10 females; age 23.6 + 6.2 years-old; height 166.5 ± 11.1 cm; weight 75.9 ± 19.3 kg) completed a 13-week undergraduate Tai Chi course. Dynamic balance was assessed at the beginning and the end of the course using the Y-Balance test. Results: Post-hoc testing showed significant improvements in anterior (P=0.007) and posterior lateral (P=0.003) reach distances with a Cohen’s d at 0.54 and 0.71 for the anterior and posterior lateral, respectively with significant improvement in right composite compared to left composite (P\u3c0.0001). Cohen’s d was 0.51 and 1.38 for the left and right composite score, respectively. Conclusions: These findings suggest that Tai Chi may be useful as an exercise regimen to increase anterior and posterior lateral dynamic balance in balance-dependent activity as measured by the Y Balance Test. The authors champion that Tai Chi may be a useful addition for a physical therapy treatment plan, preventative exercise plan, or wellness program to increase anterior and posterior lateral dynamic balance

Global communication part 1: the use of apparel CAD technology

Trends needed for improved communication systems, through the development of future computer-aided design technology (CAD) applications, is a theme that has received attention due to its perceived benefits in improving global supply chain efficiencies. This article discusses the developments of both 2D and 3D computer-aided design capabilities, found within global fashion supply chain relationships and environments. Major characteristics identified within the data suggest that CAD/CAM technology appears to be improving; however, evidence also suggest a plateau effect, which is accrediting forced profits towards information technology manufactures, and arguably compromising the industry's competitive advantage. Nevertheless, 2D CAD increases communication speed; whereas 3D human interaction technology is seen to be evolving slowly and questionably with limited success. The article discusses the findings and also presents the issues regarding human interaction; technology education; and individual communication enhancements using technology processes. These are still prevalent topics for the future developments of global strategy and cultural communication amalgamation

User interfaces for computational science: a domain specific language for OOMMF embedded in Python

Computer simulations are used widely across the engineering and science disciplines, including in the research and development of magnetic devices using computational micromagnetics. In this work, we identify and review different approaches to configuring simulation runs: (i) the re-compilation of source code, (ii) the use of configuration files, (iii) the graphical user interface, and (iv) embedding the simulation specification in an existing programming language to express the computational problem. We identify the advantages and disadvantages of different approaches and discuss their implications on effectiveness and reproducibility of computational studies and results. Following on from this, we design and describe a domain specific language for micromagnetics that is embedded in the Python language, and allows users to define the micromagnetic simulations they want to carry out in a flexible way. We have implemented this micromagnetic simulation description language together with a computational backend that executes the simulation task using the Object Oriented MicroMagnetic Framework (OOMMF). We illustrate the use of this Python interface for OOMMF by solving the micromagnetic standard problem 4. All the code is publicly available and is open source

Novel mechanisms of resistance to vemurafenib in melanoma – V600E B-Raf reversion and switching VEGF-A splice isoform expression

Targeting activating mutations in the proto-oncogene B-Raf, in melanoma, has led to increases in progression free survival. Treatment with vemurafenib, which inhibits the most common activating-mutated form of B-Raf (B-RafV600E), eventually results in resistance to therapy. VEGF-A is the principal driver of angiogenesis in primary and metastatic lesions. The bioactivity of VEGF-A is dependent upon alternative RNA splicing and pro-angiogenic isoforms of VEGF-A are upregulated in many disease states dependent upon angiogenesis, including cancers. Using techniques including RT-PCR, Western blotting, ELISA and luciferase reporter assays, the effect of vemurafenib on proliferation, ERK1/2 phosphorylation and the levels of pro- and anti-angiogenic VEGF-A isoforms was investigated in melanoma cell types expressing either wild-type B-Raf or B-RafV600E, including a primary melanoma culture derived from a highly vascularised and active nodule taken from a patient with a V600E mutant melanoma. The primary melanoma culture was characterised and found to have reverted to wild-type B-Raf. In B-RafV600E A375 cells ERK1/2 phosphorylation, pro-angiogenic VEGF-A mRNA, total VEGF-A protein expression and VEGF-A 3’UTR activity were all decreased in a concentration-dependent manner by vemurafenib. Conversely vemurafenib treatment of wild-type B-Raf cells significantly increased ERK1/2 phosphorylation, pro-angiogenic VEGF-A mRNA and total VEGF-A expression in a concentration-dependent manner. A switch to pro-angiogenic VEGF-A isoforms, with a concomitant upregulation of expression by increasing VEGF-A mRNA stability, may be an additional oncogenic and pathological mechanism in B-RafV600E melanomas, which promotes tumor-associated angiogenesis and melanoma-genesis. We have also identified the genetic reversal of B-RafV600E to wild-type in an active melanoma nodule taken from a V600E-positive patient and continued vemurafenib treatment for this patient is likely to have had a detrimental effect by promoting B-RafWT activity

Information ontrol and the exercise of power in the obstetrical encounter

Interactions between doctor and patient involve participants with unequal power and possibly different interests. While a number of studies have focused upon the doctor/patient relationship, few have examined the utility of the concept of power and its capacity to help us understand the outcome of these interactions. The information sought by pregnant women from their obstetricians is used to provide a case study of one conceptualization and test of the utility of the concept of power. Pregnant women and their obstetricians are found to have different perceptions of the information that should be exchanged during their interactions. Women generally fail to obtain the information they want. Lower social class patients desire more and obtain less information than their higher status counterparts

THE IMPACT OF MOOSE (Alces alces andersoni) ON FOREST REGENERATION FOLLOWING A SEVERE SPRUCE BUDWORM OUTBREAK IN THE CAPE BRETON HIGHLANDS, NOVA SCOTIA, CANADA

Two interacting disturbances such as stand-level defoliation by spruce budworm (Choristoneura fumiferana) and subsequent herbivory by moose (Alces alces) may affect landscapes differently than if they occurred in isolation. We studied moose (A. a. andersoni) browsing on sites disturbed approximately 25 years ago by a severe spruce budworm outbreak in a region historically dominated by balsam fir (Abies balsamea) forest on northern Cape Breton Island, Nova Scotia, Canada. Our objectives were to 1) describe the impact of a large resident moose population on post-budworm regeneration of balsam fir and white birch (Betula papyrifera), and 2) to examine the interplay between moose abundance, site conditions, and variation in post-budworm forest regeneration. Fifty-eight ran­domly located sites were sampled for composition and structural characteristics, moose browse severity, moose pellet group density, and site conditions. We used univariate general linear modelling (GLM) and multivariate redundancy analysis (RDA) to examine relationships between moose abundance as indicated by pellet-groups, site conditions, and post-budworm regeneration. Approximately 65% of all balsam fir and white birch saplings tallied were severely browsed by moose, exhibiting stunted, abnormal growth forms. Both the GLM and the RDA indicated that moose abundance was the best predictor of variation in the density of post-budworm regeneration of balsam fir and white birch. Site conditions were less useful predictors of variation in regeneration. The relationship between moose abundance and regeneration of balsam fir and white birch was positive, suggesting that moose may be more abundant in areas where regeneration is denser. Sustained, severe browsing in areas regenerating after spruce budworm outbreak may significantly inhibit future forest development and alter the well documented spruce budworm-balsam fir cyclic successional system of northern Cape Breton Island

Moose impacts on forest regeneration

Published versionTwo interacting disturbances such as stand-level defoliation by spruce budworm (Choristoneura fumiferana) and subsequent herbivory by moose (Alces alces) may affect landscapes differently than if they occurred in isolation. We studied moose (A. a. andersoni) browsing on sites disturbed approximately 25 years ago by a severe spruce budworm outbreak in a region historically dominated by balsam fir (Abies balsamea) forest on northern Cape Breton Island, Nova Scotia, Canada. Our objectives were to 1) describe the impact of a large resident moose population on post-budworm regeneration of balsam fir and white birch (Betula papyrifera), and 2) to examine the interplay between moose abundance, site conditions, and variation in post-budworm forest regeneration. Fifty-eight ran­domly located sites were sampled for composition and structural characteristics, moose browse severity, moose pellet group density, and site conditions. We used univariate general linear modelling (GLM) and multivariate redundancy analysis (RDA) to examine relationships between moose abundance as indicated by pellet-groups, site conditions, and post-budworm regeneration. Approximately 65% of all balsam fir and white birch saplings tallied were severely browsed by moose, exhibiting stunted, abnormal growth forms. Both the GLM and the RDA indicated that moose abundance was the best predictor of variation in the density of post-budworm regeneration of balsam fir and white birch. Site conditions were less useful predictors of variation in regeneration. The relationship between moose abundance and regeneration of balsam fir and white birch was positive, suggesting that moose may be more abundant in areas where regeneration is denser. Sustained, severe browsing in areas regenerating after spruce budworm outbreak may significantly inhibit future forest development and alter the well documented spruce budworm-balsam fir cyclic successional system of northern Cape Breton Island

A Development Environment for Visual Physics Analysis

The Visual Physics Analysis (VISPA) project integrates different aspects of physics analyses into a graphical development environment. It addresses the typical development cycle of (re-)designing, executing and verifying an analysis. The project provides an extendable plug-in mechanism and includes plug-ins for designing the analysis flow, for running the analysis on batch systems, and for browsing the data content. The corresponding plug-ins are based on an object-oriented toolkit for modular data analysis. We introduce the main concepts of the project, describe the technical realization and demonstrate the functionality in example applications

Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies

Summary: Genevar (GENe Expression VARiation) is a database and Java tool designed to integrate multiple datasets, and provides analysis and visualization of associations between sequence variation and gene expression. Genevar allows researchers to investigate expression quantitative trait loci (eQTL) associations within a gene locus of interest in real time. The database and application can be installed on a standard computer in database mode and, in addition, on a server to share discoveries among affiliations or the broader community over the Internet via web services protocols

Kernel Density Surface Modelling as a Means to Identify Significant Concentrations of Vulnerable Marine Ecosystem Indicators

The United Nations General Assembly Resolution 61/105, concerning sustainable fisheries in the marine ecosystem, calls for the protection of vulnerable marine ecosystems (VME) from destructive fishing practices. Subsequently, the Food and Agriculture Organization (FAO) produced guidelines for identification of VME indicator species/taxa to assist in the implementation of the resolution, but recommended the development of case-specific operational definitions for their application. We applied kernel density estimation (KDE) to research vessel trawl survey data from inside the fishing footprint of the Northwest Atlantic Fisheries Organization (NAFO) Regulatory Area in the high seas of the northwest Atlantic to create biomass density surfaces for four VME indicator taxa: large-sized sponges, sea pens, small and large gorgonian corals. These VME indicator taxa were identified previously by NAFO using the fragility, life history characteristics and structural complexity criteria presented by FAO, along with an evaluation of their recovery trajectories. KDE, a non-parametric neighbour-based smoothing function, has been used previously in ecology to identify hotspots, that is, areas of relatively high biomass/abundance. We present a novel approach of examining relative changes in area under polygons created from encircling successive biomass categories on the KDE surface to identify ‘‘significant concentrations’’ of biomass, which we equate to VMEs. This allows identification of the VMEs from the broader distribution of the species in the study area. We provide independent assessments of the VMEs so identified using underwater images, benthic sampling with other gear types (dredges, cores), and/or published species distribution models of probability of occurrence, as available. For each VME indicator taxon we provide a brief review of their ecological function which will be important in future assessments of significant adverse impact on these habitats here and elsewhere.Versión del editor4,411